Over the past few years, microfinance has been widely heralded as a successful contributor to the alleviation of poverty. Scores of studies have shown the positive impact that microfinance can have on the lives of poor people. However, overall progress has been disappointing. Achievement of poverty alleviation goals will call for new and innovative ways of working rather than more of the same. A strategic, overarching strategy to address poor people's interrelated needs through creative partnerships that build on the best of different development sectors has the potential to lead to exponential rather than incremental reduction of poverty in the developing world. Evidence now supports the integration of microfinance with non-financial services as an approach that has potential for enormous contribution to poverty alleviation. This chapter will focus on the opportunities and challenges for microfinance organizations providing these integrated services. It also will provide supporting evidence that shows promising financial and health benefits of integration for the poor and the institutions that support their self-help efforts.